(1,2,3,4-TETRAHYDRO-ISOQUINOLIN-3-YLMETHYL)-CARBAMIC ACID TERT-BUTYL ESTER - CAS 885273-85-8
Category:
Main Product
Product Name:
(1,2,3,4-TETRAHYDRO-ISOQUINOLIN-3-YLMETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
Catalog Number:
885273-85-8
Synonyms:
(1,2,3,4-TETRAHYDRO-ISOQUINOLIN-3-YLMETHYL)-CARBAMIC ACID TERT-BUTYL ESTER; 3-BOC-AMINOMETHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
CAS Number:
885273-85-8
Molecular Weight:
262.35
Molecular Formula:
C15H22N2O2
COA:
Inquire
MSDS:
Inquire
Chemical Structure
CAS 885273-85-8 (1,2,3,4-TETRAHYDRO-ISOQUINOLIN-3-YLMETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

Reference Reading


1.Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology.
Beher D1, Wrigley JD, Nadin A, Evin G, Masters CL, Harrison T, Castro JL, Shearman MS. J Biol Chem. 2001 Nov 30;276(48):45394-402. Epub 2001 Sep 26.
Intramembranous cleavage of the beta-amyloid precursor protein by gamma-secretase is the final processing event generating amyloid-beta peptides, which are thought to be causative agents for Alzheimer's disease. Missense mutations in the presenilin genes co-segregate with early-onset Alzheimer's disease, and, recently, a close biochemical linkage between presenilins and the identity of gamma-secretase has been established. Here we describe for the first time that certain potent gamma-secretase inhibitors are able to interfere with the endoproteolytic processing of presenilin 1 (PS1). In addition, we identified a novel gamma-secretase inhibitor, [1S-benzyl-4R-[1-(5-cyclohexyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3(R,S)-ylcarbamoyl)-S-ethylcarbamoyl]-2R-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester (CBAP), which not only physically interacts with PS1, but upon chronic treatment produces a "pharmacological knock-down" of PS1 fragments.