1,2,3,4-tetrahydro-4-methylquinoline - CAS 19343-78-3
Catalog number: 19343-78-3
Category: Main Product
Molecular Formula:
C10H13N
Molecular Weight:
147.2170
COA:
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Purity:
N/A
Synonyms:
AKOS BB-9864; 1,2,3,4-TETRAHYDRO-4-METHYLQUINOLINE; 1,2,3,4-tetrahydro-4-methyl-quinolin
MSDS:
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Quantity:
Data not available, please inquire.
Boiling Point:
232.6ºC at 760mmHg
Density:
0.966g/cm3
InChIKey:
OXNZWCYNCDWCJA-UHFFFAOYSA-N
InChI:
InChI=1S/C10H13N/c1-8-6-7-11-10-5-3-2-4-9(8)10/h2-5,8,11H,6-7H2,1H3
Canonical SMILES:
CC1CCNC2=CC=CC=C12
1.PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells.
Rolland M1, Li X2, Sellier Y3,4, Martin H1, Perez-Berezo T1, Rauwel B1, Benchoua A5,6, Bessières B3,4, Aziza J7, Cenac N1, Luo M2, Casper C1,8, Peschanski M5,6, Gonzalez-Dunia D1, Leruez-Ville M3,4, Davrinche C1, Chavanas S1. PLoS Pathog. 2016 Apr 14;12(4):e1005547. doi: 10.1371/journal.ppat.1005547. eCollection 2016.
Congenital infection by human cytomegalovirus (HCMV) is a leading cause of permanent sequelae of the central nervous system, including sensorineural deafness, cerebral palsies or devastating neurodevelopmental abnormalities (0.1% of all births). To gain insight on the impact of HCMV on neuronal development, we used both neural stem cells from human embryonic stem cells (NSC) and brain sections from infected fetuses and investigated the outcomes of infection on Peroxisome Proliferator-Activated Receptor gamma (PPARγ), a transcription factor critical in the developing brain. We observed that HCMV infection dramatically impaired the rate of neuronogenesis and strongly increased PPARγ levels and activity. Consistent with these findings, levels of 9-hydroxyoctadecadienoic acid (9-HODE), a known PPARγ agonist, were significantly increased in infected NSCs. Likewise, exposure of uninfected NSCs to 9-HODE recapitulated the effect of infection on PPARγ activity.
2.mTORC1-mediated downregulation of COX2 restrains tumor growth caused by TSC2 deficiency.
Li H1,2, Jin F3,4, Jiang K3,5, Ji S3, Wang L3, Ni Z3, Chen X6, Hu Z7, Zhang H8, Liu Y1, Qin Y3, Zha X3,9. Oncotarget. 2016 Apr 7. doi: 10.18632/oncotarget.8633. [Epub ahead of print]
Tuberous sclerosis complex (TSC), caused by loss-of-function mutations in the TSC1 or TSC2 gene, is characterized by benign tumor formation in multiple organs. Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) is the primary alteration underlying TSC tumors. By analyzing Tsc2-null mouse embryonic fibroblasts (MEFs) and rat uterine leiomyoma-derived Tsc2-null ELT3 cells, we detected evidence for the involvement of cyclooxygenase 2 (COX2) as a downstream target of mTORC1 in the development of TSC tumors. We showed that loss of TSC2 led to decreased COX2 expression through activation of an mTORC1/signal transducer and activator of transcription 3 (STAT3) signaling pathway. Overexpression of COX2 promoted proliferation and tumoral growth of Tsc2-null cells. COX2 knockdown inhibited the proliferation of the control cells. COX2 enhanced Tsc2-null cell growth through upregulation of interleukin-6 (IL-6). In addition, rapamycin in combination with celecoxib, a COX2 inhibitor, strongly inhibited Tsc2-deficient cell growth.
3.Genetic Variants Associated with Colorectal Adenoma Susceptibility.
Abulí A1, Castells A2, Bujanda L3, Lozano JJ4, Bessa X1, Hernández C5, Álvarez-Urturi C1, Pellisé M2, Esteban-Jurado C2, Hijona E3, Burón A5, Macià F5, Grau J6, Guayta R7, Castellví-Bel S2, Andreu M1; PROCOLON research group. PLoS One. 2016 Apr 14;11(4):e0153084. doi: 10.1371/journal.pone.0153084.
BACKGROUND: Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk.
4.SURGICAL REMOVAL OF DENSE POSTERIOR CAPSULE OPACIFICATION AND VITREOUS FLOATERS IN ADULTS BY POSTERIOR CONTINUOUS CURVILINEAR CAPSULORHEXIS THROUGH THE PARS PLANA AND 23-GAUGE VITRECTOMY.
Lin J1, Su Z, Huang X, Ji X, Yao K. Retina. 2016 Apr 13. [Epub ahead of print]
PURPOSE: To evaluate the safety and efficacy of posterior continuous curvilinear capsulorhexis through the pars plana and 23-gauge vitrectomy in surgical management of dense posterior capsule opacification and vitreous floaters.
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CAS 19343-78-3 1,2,3,4-tetrahydro-4-methylquinoline

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