1,2,3,4-Tetrahydro-2-hydroxy-6-methoxy-2-naphthalenesulfonic acid - CAS 1018123-69-7
Catalog number: 1018123-69-7
Category: Main Product
Molecular Formula:
Molecular Weight:
2-hydroxy-6-methoxy-3,4-dihydro-1H-naphthalene-2-sulfonicacid; DB-058704; 1,2,3,4-tetrahydro-2-hydroxy-6-methoxy-2-Naphthalenesulfonicacid; 1018123-69-7
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1.A Study Comparing the Efficacy of Monopolar Radiofrequency and Glycolic Acid Peels in Facial Rejuvenation of Aging Skin Using Histopathology and Ultrabiomicroscopic Sonography (UBM) - An Evidence Based Study.
Wakade DV1, Nayak CS2, Bhatt KD3. Acta Medica (Hradec Kralove). 2016;59(1):14-17. doi: 10.14712/18059694.2016.49.
BACKGROUND: Radio frequency (RF) and chemical peels have been used for nonablative skin rejuvenation. Both of these cause collagen remodeling in the dermis and neo-collagen formation resulting in facial rejuvenation. There is limited literature on the evaluation of collagen remodeling by objective methods.
2.2-Aryl-3-(2-morpholinoethyl)thiazolidin-4-ones: Synthesis, anti-inflammatory in vivo, cytotoxicity in vitro and molecular docking studies.
Pires Gouvea D1, Vasconcellos FA2, Dos Anjos Berwaldt G1, Neto AC3, Fischer G4, Sakata RP5, Almeida WP5, Cunico W6. Eur J Med Chem. 2016 Apr 20;118:259-265. doi: 10.1016/j.ejmech.2016.04.028. [Epub ahead of print]
Seven new 4-thiazolidinones bearing the morpholino moiety were easily synthesized by one-pot reactions of 4-(2-aminoethyl)morpholine (2-morpholinoethylamine), arenealdehydes and mercaptoacetic acid refluxing toluene for 19 h with moderate to good yields (45-97%). These novel compounds were fully identified and characterized by NMR spectroscopy and mass spectrometry. Thiazolidin-4-ones in vivo anti-inflammatory activities were determined using a croton oil-induced ear edema model of inflammation in BALB C mice. The best results were found for compounds 4c (49.20 mmol/kg), 4d (49.20 mmol/kg) and 4f (52.48 mmol/kg), which showed the ability to decrease the ear edema in mice by 50%, 48% and 54%, respectively, when compared to the standard drug indomethacin. In addition, the in vitro cytotoxicity activity of thiazolidin-4-ones against Vero cells was also performed and four compounds (4a, 4c, 4d and 4f) showed no toxic effect at 500 μg/mL. A docking simulation of compounds into the 1Q4G (COX-1) and 4PH9 (COX-2) enzymes binding site was conducted.
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CAS 1018123-69-7 1,2,3,4-Tetrahydro-2-hydroxy-6-methoxy-2-naphthalenesulfonic acid

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