1,2,3,4-Tetra-O-benzyl-a-D-mannopyranoside - CAS 57783-76-3
Product Name:
Benzyl 2,3,4-tri-O-benzyl-a-D-mannopyranoside
CAS Number:
Molecular Weight:
Molecular Formula:
Chemical Structure
CAS 57783-76-3 1,2,3,4-Tetra-O-benzyl-a-D-mannopyranoside

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Reference Reading

1.Presumed Sterile Endophthalmitis After Intravitreal Triamcinolone (Kenalog)-More Common and Less Benign Than We Thought?
Fong AH1, Chan CK. Asia Pac J Ophthalmol (Phila). 2016 Apr 11. [Epub ahead of print]
PURPOSE: This study aimed to review the incidence and clinical outcome of presumed sterile endophthalmitis after the off-label use of intravitreal Kenalog injections (triamcinolone acetonide with 1.5% benzyl alcohol) and to compare it with the presumed sterile endophthalmitis incidence after intravitreal Kenacort-A (0.99% benzyl alcohol) at our center.
2.Intense THz source based on BNA organic crystal pumped at Ti:sapphire wavelength.
Shalaby M, Vicario C, Thirupugalmani K, Brahadeeswaran S, Hauri CP. Opt Lett. 2016 Apr 15;41(8):1777-80. doi: 10.1364/OL.41.001777.
We report on high-energy terahertz pulses by optical rectification (OR) in the organic crystal N-benzyl-2-methyl-4-nitroaniline (BNA) directly pumped by a conventional Ti:sapphire amplifier. The simple scheme provides an optical-to-terahertz conversion efficiency of 0.25% when pumped by collimated laser pulses with a duration of 50 fs and a central wavelength of 800 nm. The generated radiation spans frequencies between 0.2 and 3 THz. We measured the damage threshold, as well as the dependency of the conversion efficiency on the pump fluence, pump wavelength, and pulse duration.
3.Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids.
Benítez D1, Medeiros A1,2, Fiestas L1, Panozzo-Zenere EA3, Maiwald F4, Prousis KC5, Roussaki M6, Calogeropoulou T5, Detsi A6, Jaeger T7, Šarlauskas J8, Peterlin Mašič L9, Kunick C4, Labadie GR3, Flohé L2,10, Comini MA1. PLoS Negl Trop Dis. 2016 Apr 12;10(4):e0004617. doi: 10.1371/journal.pntd.0004617. eCollection 2016.
BACKGROUND: The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis. The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione, T(SH)2], a low molecular mass cosubstrate absent in the host. In pathogenic trypanosomatids, a single enzyme, trypanothione synthetase (TryS), catalyzes trypanothione biosynthesis, which is indispensable for parasite survival. Thus, TryS qualifies as an attractive drug target candidate.
4.Stereoselective Synthesis and Modelling-Driven Optimisation of Carane-Based Aminodiols and 1,3-Oxazines as Catalysts for the Enantioselective Addition of Diethylzinc to Benzaldehyde.
Szakonyi Z1, Csőr Á1, Csámpai A2, Fülöp F3. Chemistry. 2016 Apr 13. doi: 10.1002/chem.201600749. [Epub ahead of print]
The reductive amination of (-)-2-carene-3-aldehyde, prepared in two steps from (-)-perillaldehyde, furnished 2-carene-based allylamines. tert-Butyloxycarbonyl (Boc) or carbobenzyloxy (Cbz) protection of the resulting amines, followed by stereoselective dihydroxylation in highly stereospecific reactions with OsO4 and subsequent deprotection, resulted in N-benzylaminodiols, which were transformed to primary and tertiary aminodiols. The reactions of the N-benzyl- and N-(1-phenylethyl)-substituted derivatives with formaldehyde led to highly regioselective ring closure, resulting in carane-fused 1,3-oxazines. The aminodiols and their 1,3-oxazine derivatives were applied as chiral catalysts in the enantioselective addition of diethylzinc to aldehydes. The best (R) enantioselectivity was observed in the case of the N-((R)-1-phenylethyl)-substituted aminodiol, whereas the opposite chiral direction was preferred when the 1,3-oxazines were applied.