1,2,3,4-Tetra-O-acetyl-b-D-glucuronide methyl ester - CAS 7355-18-2
Category:
Carbohydrates
Product Name:
1,2,3,4-Tetra-O-acetyl-b-D-glucuronide methyl ester
Synonyms:
Methyl 1,2,3,4-tetra-O-acetyl-b-D-glucopyranuronate; Methyl(1,2,3,4-tetra-O-acetyl-b-D-glucopyranoside)uronate
CAS Number:
7355-18-2
Molecular Weight:
376.31
Molecular Formula:
C15H20O11
COA:
Inquire
MSDS:
Inquire
Structure:
Monosaccharides
Chemical Structure
CAS 7355-18-2 1,2,3,4-Tetra-O-acetyl-b-D-glucuronide methyl ester

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Reference Reading


1.One-Pot Three-Component Synthesis of Novel Diethyl((2-oxo-1,2-dihydroquinolin-3-yl)(arylamino)methyl)phosphonate as Potential Anticancer Agents.
Fang YL1,2, Wu ZL3, Xiao MW4, Tang YT5, Li KM6, Ye J7, Xiang JN8, Hu AX9. Int J Mol Sci. 2016 Apr 29;17(5). pii: E653.
With the aim of discovering new anticancer agents, we have designed and synthesized novel α-aminophosphonate derivatives containing a 2-oxoquinoline structure using a convenient one-pot three-component method. The newly synthesized compounds were evaluated for antitumor activities against the A549 (human lung adenocarcinoma cell), HeLa (human cervical carcinoma cell), MCF-7 (human breast cancer cell), and U2OS (human osteosarcoma cell) cancer cell lines in vitro, employing a standard 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay. The results of pharmacological screening indicated that many compounds exhibited moderate to high levels of antitumor activities against the tested cancer cell lines and that most compounds showed more potent inhibitory activities comparable to 5-fluorouracil (5-FU) which was used as a positive control. The mechanism of representative compound 4u (diethyl((2-oxo-1,2-dihydroquinolin-3-yl)(phenyl-amino)methyl)phosphonate) indicated that the compound mainly arrested HeLa cells in S and G2 stages and was accompanied by apoptosis in HeLa cells.