1,2,3,4-Tetra-O-acetyl-6-O-(2,3,4,6-tetra-O-acetyl-a-D-mannopyranosyl)-D-mannopyrannose - CAS 72691-29-3
Category:
Carbohydrates
Product Name:
1,2,3,4-Tetra-O-acetyl-6-O-(2,3,4,6-tetra-O-acetyl-a-D-mannopyranosyl)-D-mannopyrannose
Synonyms:
Acetyl-6-O-(2,3,4,6-tetra-O-acetyl-a-D-mannopyranosyl)-2,3,4-tri-O-acetyl-D-mannopyrannose; 6-O-(2,3,4,6-Tetra-O-acetyl-a-D-mannopyranosyl)-D-mannopyranose tetraacetate
CAS Number:
72691-29-3
Related CAS:
123809-60-9
Molecular Weight:
678.59
Molecular Formula:
C28H38O19
COA:
Inquire
MSDS:
Inquire
Structure:
Oligosaccharides
Chemical Structure
CAS 72691-29-3 1,2,3,4-Tetra-O-acetyl-6-O-(2,3,4,6-tetra-O-acetyl-a-D-mannopyranosyl)-D-mannopyrannose

Related Oligosaccharides Products


Reference Reading


1.A fucoidan from Nemacystus decipiens disrupts angiogenesis through targeting bone morphogenetic protein 4.
Wang W1, Chen H1, Zhang L1, Qin Y1, Cong Q1, Wang P1, Ding K2. Carbohydr Polym. 2016 Jun 25;144:305-14. doi: 10.1016/j.carbpol.2016.02.068. Epub 2016 Feb 26.
A sulfated and acetylated fucoidan, named NDH01, was extracted from seaweed Nemacystus decipiens. NDH01 was composed of mannose, glucuronic acid, fucose, sulfate group and acetyl group in the molar ratio of 3.0: 14.4: 82.6: 34.3: 13.9. The backbone of NDH01 was fucose-free core, composed of α-d-1,2-Manp and β-d-1,4-GlcpA disaccharide repeat unit. The branches were attached at the C3, C4 and C6 of α-d-1,2-Manp. The sidechain was composed of α-l-1,3,4-Fucp, α-l-1,4-Fucp, α-l-1,3-Fucp and α-l-1,4-GlcpA. The sulfate group was linked to C4 of α-l-1,3,4-Fucp, whereas, acetyl group was branched on C2 of α-l-1,2,3-Fucp. NDH01 could disrupt tube formation and inhibit the migration as well as cell growth of human microvascular endothelial cells. Besides, phosphorylation of Smad/1/5/8, Erk and FAK was significantly inhibited by NDH01. Further studies uncovered that NDH01 blocked Smad1/5/8 signaling via interacting with bone morphogenetic protein 4 and downregulating bone morphogenetic protein 4 expression.