1-[2-(2-Azidoethoxy)ethoxyethyl]-2,3,4,6-tetra-O-acetyl-D-galactopyranoside - CAS 381716-33-2
Category:
Carbohydrates
Product Name:
1-[2-(2-Azidoethoxy)ethoxyethyl]-2,3,4,6-tetra-O-acetyl-D-galactopyranoside
Synonyms:
2,3,4,6-Tetra-O-acetyl-b-D-galactopyranosyl PEG3-azide
CAS Number:
381716-33-2
Molecular Weight:
505.47
Molecular Formula:
C20H31N3O12
COA:
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MSDS:
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Structure:
Monosaccharides
Chemical Structure
CAS 381716-33-2 1-[2-(2-Azidoethoxy)ethoxyethyl]-2,3,4,6-tetra-O-acetyl-D-galactopyranoside

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Reference Reading


1.Development of a high-affinity inhibitor of the prostaglandin transporter.
Chi Y1, Min J, Jasmin JF, Lisanti MP, Chang YT, Schuster VL. J Pharmacol Exp Ther. 2011 Nov;339(2):633-41. doi: 10.1124/jpet.111.181354. Epub 2011 Aug 17.
Prostaglandin E(2) (PGE(2)) triggers a vast array of biological signals and physiological events. The prostaglandin transporter (PGT) controls PGE(2) influx and is rate-limiting for PGE(2) metabolism and signaling termination. PGT global knockout mice die on postnatal day 1 from patent ductus arteriosus. A high-affinity PGT inhibitor would thus be a powerful tool for studying PGT function in adult animals. Moreover, such an inhibitor could be potentially developed into a therapeutic drug targeting PGT. Based on structure-activity relationship studies that built on recently identified inhibitors of PGT, we obtained N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4-((4-((2-(2-(2-benzamidoethoxy)ethoxy)ethyl)amino)-6-((4-hydroxyphenyl)amino)-1,3,5-triazin-2-yl)amino)benzamide (T26A), a competitive inhibitor of PGT, with a K(i) of 378 nM. T26A seems to be highly selective for PGT, because it neither interacts with a PGT homolog in the organic anion transporter family nor affects PGE(2) synthesis.