1,1-Dibromo-3,3,3-trifluoroacetone - CAS 431-67-4
Catalog number: 431-67-4
Category: Main Product
Molecular Formula:
C3HOBr2F3
Molecular Weight:
269.84
COA:
Inquire
Purity:
98%
Appearance:
Light-Orange Liquid
Synonyms:
1,1-DIBROMO-3,3,3-TRIFLUOROACETONE; 3,3-DIBROMO-1,1,1-TRIFLUOROACETONE; 1,1-Dibromo-3,3,3-trifluoroacetone 97%; 1,1-Dibromo-3,3,3-trifluoroacetone97%; 3,3-Dibromo-1,1,1-trifluoropropan-2-one
Storage:
-20ºC Freezer
MSDS:
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Application:
Used in synthesis of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors.
Quantity:
Data not available, please inquire.
Boiling Point:
163.1ºC at 760 mmHg
Melting Point:
111ºC
Density:
1.98
InChIKey:
HEPPAPZASXFWTB-UHFFFAOYSA-N
InChI:
InChI=1S/C3HBr2F3O/c4-2(5)1(9)3(6,7)8/h2H
Canonical SMILES:
C(C(=O)C(F)(F)F)(Br)Br
1.Biotransformation of 2,3,3,3-tetrafluoropropene (HFO-1234yf).
Schuster P1, Bertermann R, Snow TA, Han X, Rusch GM, Jepson GW, Dekant W. Toxicol Appl Pharmacol. 2008 Dec 1;233(2):323-32. doi: 10.1016/j.taap.2008.08.018. Epub 2008 Sep 11.
2,3,3,3-Tetrafluoropropene (HFO-1234yf) is a non-ozone-depleting fluorocarbon replacement with a low global warming potential which has been developed as refrigerant. The biotransformation of HFO-1234yf was investigated after inhalation exposure. Male Sprague-Dawley rats were exposed to air containing 2000, 10,000, or 50,000 ppm HFO-1234yf for 6 h and male B6C3F1 mice were exposed to 50,000 ppm HFO-1234yf for 3.5 h in a dynamic exposure chamber (n=5/concentration). After the end of the exposure, animals were individually housed in metabolic cages and urines were collected at 6 or 12-hour intervals for 48 h. For metabolite identification, urine samples were analyzed by (1)H-coupled and decoupled (19)F-NMR and by LC/MS-MS or GC/MS. Metabolites were identified by (19)F-NMR chemical shifts, signal multiplicity, (1)H-(19)F coupling constants and by comparison with synthetic reference compounds. In all urine samples, the predominant metabolites were two diastereomers of N-acetyl-S-(3,3,3-trifluoro-2-hydroxy-propyl)-l-cysteine.
2.Radiochemical analysis of 93Zr.
Espartero AG1, Suárez JA, Rodríguez M, Piña G. Appl Radiat Isot. 2002 Jan-Feb;56(1-2):41-6.
The zirconium isotope 93Zr is a long-lived pure beta-particle-emitting radionuclide, which is produced by nuclear fission and neutron activation of the stable isotope 92Zr. This element is a constituent of the structural components of nuclear reactor vessels. A selective liquid-liquid extraction method for radiochemical separation of Zr, based on liquid-liquid extraction with 1-(2'-thenoyl)-3,3,3-trifluoroacetone in xylene and a subsequent stripping of 93Zr by an aqueous acid solution, has been developed. The method was utilised to separate Zr from other pure beta-particle and beta-gamma emitters in different kinds of samples. Decontamination factors higher than 99% for the pure beta-particle and beta-gamma emitters and an overall chemical yield of 80% were obtained. The sensitivity of the method allows the determination of the isolated 93Zr by liquid scintillation counting and the minimum detectable activity value obtained was 0.067 Bq over a counting period of 60 min.
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CAS 431-67-4 1,1-Dibromo-3,3,3-trifluoroacetone

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