1,1'-Biphenyl,2,4-difluoro-4'-methoxy- - CAS 90101-30-7
Catalog number: 90101-30-7
Category: Main Product
Molecular Formula:
C13H10 F2 O
Molecular Weight:
Data not available, please inquire.
1.Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).
Getlik M1, Smil D2, Zepeda-Velázquez C1, Bolshan Y2, Poda G1,3, Wu H2, Dong A2, Kuznetsova E2, Marcellus R1, Senisterra G2, Dombrovski L2, Hajian T2, Kiyota T1, Schapira M2,4, Arrowsmith CH2, Brown PJ2, Vedadi M2,4, Al-Awar R1,4. J Med Chem. 2016 Mar 24;59(6):2478-96. doi: 10.1021/acs.jmedchem.5b01630. Epub 2016 Mar 9.
WD repeat-containing protein 5 (WDR5) is an important component of the multiprotein complex essential for activating mixed-lineage leukemia 1 (MLL1). Rearrangement of the MLL1 gene is associated with onset and progression of acute myeloid and lymphoblastic leukemias, and targeting the WDR5-MLL1 interaction may result in new cancer therapeutics. Our previous work showed that binding of small molecule ligands to WDR5 can modulate its interaction with MLL1, suppressing MLL1 methyltransferase activity. Initial structure-activity relationship studies identified N-(2-(4-methylpiperazin-1-yl)-5-substituted-phenyl) benzamides as potent and selective antagonists of this protein-protein interaction. Guided by crystal structure data and supported by in silico library design, we optimized the scaffold by varying the C-1 benzamide and C-5 substituents. This allowed us to develop the first highly potent (Kdisp < 100 nM) small molecule antagonists of the WDR5-MLL1 interaction and demonstrate that N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide 16d (OICR-9429) is a potent and selective chemical probe suitable to help dissect the biological role of WDR5.
2.Red Phosphorescent Bis-Cyclometalated Iridium Complexes with Fluorine-, Phenyl-, and Fluorophenyl-Substituted 2-Arylquinoline Ligands.
Kim J1, Lee KH1, Lee SJ2, Lee HW2, Kim YK3, Kim YS4, Yoon SS5. Chemistry. 2016 Mar 14;22(12):4036-45. doi: 10.1002/chem.201504392. Epub 2016 Feb 16.
Red phosphorescent iridium(III) complexes based on fluorine-, phenyl-, and fluorophenyl-substituted 2-arylquinoline ligands were designed and synthesized. To investigate their electrophosphorescent properties, devices were fabricated with the following structure: indium tin oxide (ITO)/4,4',4''-tris[2-naphthyl(phenyl)amino]triphenylamine (2-TNATA)/4,4'-bis[N-(1-naphthyl)-N-phenylamino]biphenyl (NPB)/4,4'-bis(N-carbazolyl)-1,1'-biphenyl (CBP): 8 % iridium (III) complexes/bathocuproine (BCP)/tris(8-hydroxyquinolinato)aluminum (Alq3 )/8-hydroxyquinoline lithium (Liq)/Al. All devices, which use these materials showed efficient red emissions. In particular, a device exhibited a saturated red emission with a maximum luminance, external quantum efficiency, and luminous efficiency of 14200 cd m(-2) , 8.44 %, and 6.58 cd A(-1) at 20 mA cm(-2) , respectively. The CIE (x, y) coordinates of this device are (0.67, 0.33) at 12.0 V.
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CAS 90101-30-7 1,1'-Biphenyl,2,4-difluoro-4'-methoxy-

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