1.Lurasidone adjunctive with lithium or valproate for bipolar depression: A placebo-controlled trial utilizing prospective and retrospective enrolment cohorts.
Suppes T1, Kroger H2, Pikalov A2, Loebel A3. J Psychiatr Res. 2016 Mar 31;78:86-93. doi: 10.1016/j.jpsychires.2016.03.012. [Epub ahead of print]
In this study, designed to evaluate the efficacy of lurasidone as adjunctive therapy with lithium or valproate, patients with bipolar I depression were randomized to 6 weeks of double-blind treatment with lurasidone (N = 180) or placebo (N = 176), added to background treatment with lithium or valproate. All patients were treated with lithium or valproate for a minimum of 4 weeks prior to screening. This was confirmed either by prospective treatment after study enrolment (run-in cohort), or retrospectively, with blood levels of lithium and valproate at screening (non-run-in cohort). Primary and key secondary endpoints were change from baseline to week 6 on the Montgomery-Åsberg Depression Rating Scale (MADRS) and depression severity score on the Clinical Global Impressions scale for use in bipolar illness (CGI-BP-S), respectively. Treatment with lurasidone was associated with non-significant improvement at week 6 vs. placebo for the MADRS total score (-11.
2.What is the Profile of Individuals Joining the KNEEguru Online Health Community? A Cross-Sectional Mixed-Methods Study.
Bright P1, Hambly K, Tamakloe S. J Med Internet Res. 2016 Apr 18;18(4):e84. doi: 10.2196/jmir.5374.
BACKGROUND: The use of the Internet for seekers of health-related information provides convenience and accessibility to diverse sources (of variable quality) for many medical conditions. There is a suggestion that patients may find empowerment by engaging with Internet health care strategies and communities. The profile of consumers of online health information on knee pain has not been explored.
3.Pilot Study on the Homeopathic Treatment of Binge Eating in Males.
van Heerden HJ, Razlog R, Pellow J. Altern Ther Health Med. 2016 Apr;22 Suppl 1:8-13.
Context • Frequent binge eating is often a symptom of an underlying eating disorder, such as bulimia nervosa (BN) or binge eating disorder (BED). The role of homeopathy in the treatment of binge eating remains poorly explored. Objective • The study intended to measure the efficacy of individualized homeopathic treatment for binge eating in adult males. Design • This case study was a 9-wk pilot using an embedded, mixed-methods design. A 3-wk baseline period was followed by a 6-wk treatment period. Setting • The setting was the Homeopathic Health Clinic at the University of Johannesburg in Johannesburg, South Africa. Participants • Through purposive sampling, the research team recruited 15 Caucasian, male participants, aged 18-45 y, who were exhibiting binge eating. Intervention • Individualized homeopathic remedies were prescribed to each participant. Primary Outcome Measures • Participants were assessed by means of (1) a self-assessment calendar (SAC), recording the frequency and intensity of binging; (2) the Binge Eating Scale (BES), a psychometric evaluation of severity; and (3) case analysis evaluating changes with time.
4.Treatment of Ankylosing Spondylitis With a Bushen-Qiangdu-Zhilv Decoction: A Case Report With a 3-year Follow-up.
Zhou YY, Lin JH, Huang RY, He YT. Altern Ther Health Med. 2016 Apr;22 Suppl 1:36-40.
Context • Ankylosing spondylitis (AS) is a refractory rheumatic disease, characterized by sacroiliitis and structural damage, and over decades, it can lead to joint fusion, frequently followed by significant spinal deformity and disability. However, to date, no method has been found to be effective in relieving or blocking structural damage to joints. Objective • The study intended to show that a decoction of Bushen-Qiangdu-Zhilv (BQZ), a therapy used in traditional Chinese medicine (TCM), can provide an alternative treatment for AS patients. Design • The research team performed a case study. Setting • The study was conducted at Guangdong Provincial Hospital of TCM in Guangzhou, China. Participant • The case study involved a 33-y-old male patient with active AS who visited the research team's clinic. Intervention • The patient took the BQZ orally 2 ×/d at 30 min after breakfast and 30 min after dinner. The patient returned to the clinic for consultation monthly.